[The changes of serum levels of interleukin-6 and interleukin-8 in pregnant women with systemic lupus erythematosus].
摘要
OBJECTIVE: To assess the changes of serum levels of interleukin-6(IL-6) and interleukin-8 (IL-8) in pregnant women with stationary phase systemic lupus erythematosus (SLE). METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-6 and IL-8 from 14 pregnant women with stationary phase SLE (SLE group), 12 normal pregnant women (normal pregnant group) and 12 normal non-pregnant women (group normal non-pregnant). The later two groups are set as controls. RESULTS: The IL-6, IL-8 levels in group SLE patients are (20.31 +/- 5.70) ng/L and (48.80 +/- 9.17) ng/L, significantly higher than those in normal pregnant group [IL-6, IL-8 levels are (8.40 +/- 2.49) ng/L and (21.15 +/- 5.21) ng/L, respectively, P < 0.01)] and normal non-pregnant group [IL-6, IL-8 levels are (6.14 +/- 0.86) ng/L and (17.71 +/- 4.43) ng/L, respectively, P < 0.01]. However, there's no significant difference between the normal pregnant group and normal non-pregnant group (P > 0.05). CONCLUSION: Serum levels of IL-6, IL-8 may be helpful to monitor the progress of SLE during pregnancy.