Toxicological Evaluation of 504P： An Adhesive Blocking Agent for Vas Deferens
摘要
Toxicological studies on an adhesive blocking agent for vas deferens were carried out.It could be excreted from the body soon after some of the agent had been absorbed. No long-term accumulation phenomenon and no obvious effect of acute toxicity on rodent animals have been observed. The parameters of physiology, blood cells and blood biochemistry were not affected apparently. The histomorphological study showed that the blocked part of vas deferens was obliterated with fibrous tissue and sperm deposition was found in the blocked end toward epididymis. The agent had no carcinogenic effect. Moreover, on the basis of mutation assay with Salmonella typhimarium strains, analysis of chromosome aberration, mieronuclei assay in bone marrow cells of mouse and domirrant lethal mutation assay, it was shown that the agent had no mutagenic effect.