心肌梗死合并心力衰竭患者于干细胞动员后血中EPCs与BNP相关性研究
摘要
Objective: It is to observe the correlation between circulating endothelial progenitor cells (endothelial progenitor cells, EPCs) and brain natriuretic peptide (BNP) in patients with myocardial infarction and heart failure after stem cell mobilizer granulocyte colony stimulating factor (granulocyte colony stimulating factor, G-CSF). Methods: Patients were divided into the control group(37) and the observation group (38). The observation group took injection of G-CSF, 10μg/kg, for 7d. The Two groups were observed the amount of circulating EPCs , the levels of BNP, TNF- α and other indicators, and make clinical analysis. Results: Compared with control group, the amount of EPCs were significantly increased, the level of BNP, TNF- α were decreased, the difference between the observation group and control group is statistical significant ( P < 0.05); the amount of EPCs had negative correlation with BNP. Conclusion: The application of stem cell mobilization of circulating EPCs can improve the clinical curative effect of myocardial infarction patients and heart failure, cyclic EPCs and BNP detection can effectively evaluate the heart function and prognosis.