Sequence-specific Hydrolysis of Single-stranded DNA by PNA-Cerium （IV） Adduct

2005中国化学快报：英文版Biochemistry, Genetics and Molecular Biology被引 1

摘要

A novel artificial site specific cleavage reagent, with peptide nucleic acid (PNA) as sequence-recognizing moiety and cerium (Ⅳ) ions as scissors for cleaving target DNA, was synthesized. Subsequently, it was employed in the cleavage of target 26-mer single-stranded DNA (ssDNA), which has 10-mer sequence complementary with PNA recognizer in the hybrids,under physiological conditions. Reversed-phase high-performance liquid chromatogram (RPHPLC) experiments indicated that the artificial site specific cleavage reagent could cleave the target DNA specifically.

引用本文（GB/T 7714）

He, Bai, Shen, 等. Sequence-specific Hydrolysis of Single-stranded DNA by PNA-Cerium （IV） Adduct[J]. 中国化学快报：英文版, 2005.

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