AMID ,an AIF homologous protein ,induces caspases—independent apoptosis
摘要
AIF is a mitochondrial flavoprotein that triggers caspase-independent apoptosis. We cloned and characterized a novel AIF homologous molecule designated as AMID (AIF-homologous Mitochondrion-associated Inducer of Death. AMID lacks a mitochondrial localization sequence but shares significant homology with AIF and NADH-oxidoreductases from bacteria to mammalian species. Immunofluorescent staining and biochemical experiments indicated that AMID was co-localized with mitochondria. Overexpression of AMID
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MinWu, Zhonghezhai. AMID ,an AIF homologous protein ,induces caspases—independent apoptosis[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2002.
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