Evaluation of skin irritation and anti-inflammatory effects of dandelion extract
摘要
In this study， the safety and efficacy of dandelion extract as an additive ingredient in skin cosmetics and skin topical reagents was studied by exploring multiple skin irritation tests of dandelion extract on white rabbits and skin model irritation， and evaluating its anti-inflammatory activity through human dermal fibroblasts. Multiple skin irritation tests on rabbits and skin model experiments showed that dandelion extract had no skin irritation. After histamine intervention in human dermal fibroblasts， the inflammatory factors IL-6 and IL-8 in dandelion extract group were reduced， indicating that dandelion extract had good anti-inflammatory properties. The results show that dandelion extract， as an effective natural ingredient， is relatively safe and reliable， and has a good anti-inflammatory effect， which has a great application prospect in cosmetic raw materials.