[Bioactive substances delivery for bone repair via nanocomposites: advantages, mechanisms, and emerging trends].
摘要
Objective: The advantages, mechanisms, and advances in nanocomposites for delivering bioactive substances in bone tissue engineering were systematically reviewed. Methods: This review provides a comprehensive analysis by conducting an in-depth retrieval of relevant literature and integrating it with related work from our research team. Results: Capitalizing on their inherent size effects and tunable structures, nanocomposites exhibit high drug-loading capacity and controlled/targeted delivery, allowing for the co-delivery of diverse molecules. This smart delivery capability, responsive to specific pathological or external cues, facilitates on-demand precision release to execute multiple therapeutic functions, including osteogenesis, antibacterial action, and immunomodulation. Conclusion: Nanocomposites demonstrate high delivery efficiency and controlled release kinetics, with the potential for future clinical translation of their multi-signal responsive and spatiotemporally precise drug release capabilities.