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[The role and mechanism of branched-chain amino acids in tumorigenesis and progression].

Ren ZhengChen-Chen HuYuan-Jie SunFeiming HuLin GuoHE Yuan-liShu-Ya Yang

2025PubMedBiochemistry, Genetics and Molecular Biology被引 1

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摘要

As essential amino acids, branched-chain amino acids (BCAAs) have attracted much attention in the field of tumor metabolism in recent years. This article reviews the metabolic characteristics of BCAAs in tumors and discusses their involvement in tumorigenesis and development through regulating signaling pathways, affecting the immune microenvironment, and promoting tumor metastasis. Research has shown that abnormal BCAA metabolism is closely related to the occurrence, progression, and prognosis of various tumors. By regulating BCAA metabolism, it is expected to provide new targets and strategies for tumor treatment. Indepth research on the specific mechanisms of BCAAs in tumors will provide more evidence for precision cancer treatment.

引用本文(GB/T 7714)

Ren Zheng, Chen-Chen Hu, Yuan-Jie Sun, 等. [The role and mechanism of branched-chain amino acids in tumorigenesis and progression].[J]. PubMed, 2025.

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DOI:https://doi.org/10.13294/j.aps.2025.0089

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