Risk Factors for Severe Acute Pancreatitis Complicated with Acute Lung Injury: a Meta-analysis
摘要
Background Acute lung injury represents the most probable organ injury in the context of severe acute pancreatitis, with the exception of the pancreas, which is primarily distinguished by respiratory insufficiency, manifested as shortness of breath, cyanosis, and diminished lung compliance. Nevertheless, the precise pathogenesis remains incompletely elucidated. Despite the administration of protective measures, the quality of life of patients with severe acute pancreatitis complicated by acute lung injury remains adversely affected. Objective To systematically evaluate the risk factors of severe acute pancreatitis complicated with acute lung injury. Methods Computer searches were conducted on CNKI, Wanfang database, VIP, PubMed, Web of Science and EBSCO databases to search relevant studies on the risk factors of severe acute pancreatitis complicated with lung injury from the establishment of the database to October 2023. Two researchers independently screened literature, extracted data, evaluated literature quality and evidence level, and conducted meta-analysis using RevMan 5.3 software. Begg's test in Stata17.0 was used for publication bias analysis. Results A total of 10 studies were included, all of which were case-control studies, including 1 053 patients with severe acute pancreatitis. The results of meta-analysis showed that increased age (SMD=0.58, 95%CI=0.03-1.14, P=0.04), elevated fasting blood glucose (SMD=0.45, 95%CI=0.27-0.64, P<0.000 01), and an elevated respiratory rate (>30 breaths/min) (OR=6.18, 95%CI=3.20-11.94, P<0.000 01), the occurrence of fever (OR=12.92, 95%CI=4.41-37.84, P<0.000 01), the occurrence of pleural effusion (OR=7.19, 95%CI=3.25-15.91, P<0.000 01), decreased albumin (SMD=-0.77, 95%CI=-0.98 to -0.56, P<0.000 01), combined with obesity (OR=3.11, 95%CI=1.94-4.98, P<0.000 01), decreased calcium ion (SMD=-0.63, 95%CI=-0.85 to -0.42, P<0.000 01), combined with acidosis (OR=2.15, 95%CI=1.03-4.49, P=0.04), eleva