[Pinostrobin targets the PI3K/AKT/CCL<sub>2</sub> axis in intestinal epithelial cells to inhibit intestinal macrophage infiltration and alleviate dextran sulfate sodium-induced colitis in mice].

Keni Zhang、Tong Qiao、Lin Yin、Ju Huang、Zhijun Geng、Lugen Zuo、Jianguo Hu、Jing Li

2025PubMedMedicine被引 1

摘要

OBJECTIVES: To investigate the mechanism through which pinostrobin (PSB) alleviates dextran sulfate sodium (DSS)-induced colitis in mice. METHODS: -mediated macrophage migration was assessed using Transwell assay. Network pharmacology analysis was performed to predict the key pathways that mediate the therapeutic effect of PSB. RESULTS: signaling as the core targets of PSB. CONCLUSIONS: secretion, and blocking macrophage chemotaxis and migration, highlighting the potential of PSB as a novel natural compound for treatment of inflammatory bowel disease.

引用本文（GB/T 7714）

Keni Zhang, Tong Qiao, Lin Yin, 等. [Pinostrobin targets the PI3K/AKT/CCL<sub>2</sub> axis in intestinal epithelial cells to inhibit intestinal macrophage infiltration and alleviate dextran sulfate sodium-induced colitis in mice].[J]. PubMed, 2025.

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DOI：https://doi.org/10.12122/j.issn.1673-4254.2025.10.16

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