脑机接口在中枢神经系统疾病康复中的应用
摘要
<sec><title>Objective</title> To investigate the relationship between cortical silent period (CSP) and chronic pain in patients with lumbar disc herniation (LDH), and to provide an objective, sensitive, and accurate electrophysiological indicator for chronic pain assessment in clinical practice. </sec><sec><title>Methods</title> A total of 61 patients with LDH admitted to Tongji Hospital, Shanghai, between March and December 2023 were enrolled. Based on the Numerical Rating Scale (NRS), patients were divided into mild pain group (<italic>n</italic>=22) and moderate pain group (<italic>n</italic>=39). Cortical excitability parameters [resting motor threshold (rMT) and CSP] and surface electromyography (sEMG) signals, including time-domain indices [average EMG (AEMG), root mean square (RMS), and integrated EMG (iEMG)] and frequency-domain indices \[mean power frequency (MPF) and median frequency (MF)] were compared between the two groups. Correlations between CSP and sEMG parameters were also analyzed. </sec><sec><title>Results</title> (1) rMT and CSP：Compared with the mild pain group, the CSP on the herniated side was significantly shorter in the moderate pain group (<italic>P</italic><0.05). There were no statistically significant differences in CSP on the non-herniated side or in rMT on either side (<italic>P</italic>>0.05). (2) sEMG：Compared with the same side in the mild pain group, the iEMG, AEMG, and RMS values were significantly lower in the moderate pain group (<italic>P</italic><0.05), whereas MPF and MF were significantly higher (<italic>P</italic><0.05). (3) Correlation between CSP and sEMG：Bilateral CSP was positively correlated with time-domain sEMG parameters (iEMG, AEMG, RMS) (<italic>P</italic><0.05). </sec><sec><title>Conclusion</title> Chronic pain in LDH patients is associated with altered cortical inhibition. CSP is closely related to both the severity of chronic pain and muscle function, suggesting that CSP could serve as an object