乳酸菌调控宿主脂肪代谢的研究进展
摘要
<p indent="0mm">Lipid metabolism disorder is one of the main factors causing metabolic syndrome. In animal models displaying disrupted fat metabolism or in clinical populations affected by obesity, there are substantial changes in the diversity and composition of gut microbiota, particularly within the genus <italic>Lactobacillus</italic>. As a probiotic, <italic>Lactobacillus</italic> is expected to extensively impact host fat metabolism. Therefore, this study explored the relationship between <italic>Lactobacillus</italic> and fat metabolism. It analyzed the underlying molecular mechanisms by which metabolites of <italic>Lactobacillus</italic> (such as short-chain fatty acids, bile acids, exopolysaccharides, and linoleic acid) regulate fat metabolism. Additionally, the study elaborated on the differences between the same and different <italic>Lactobacillus</italic> complexes to clarify the mechanism of lactic acid bacteria in regulating host fat metabolism. This study aims to provide perspectives and references for controlling food-borne metabolic diseases caused by lipid metabolism disorders.