Cs-GRP78 Recognition Site on Dengue Virus Envelope Protein:<i>in silico</i>perspective

Abdo A. Elfiky、Ahmed Amr、A.I. Mosaad、Ahmed K Mubarak、Mohamed Sayed、Kholoud K. El-Halwany

2023Future VirologyMedicine被引 5

摘要

Aim: To understand the binding of the dengue virus (DENV) envelope and the host cell factor, GRP78. Materials & methods: In this study, we simulate the binding of the DENV envelope against GRP78 using structural bioinformatics tools. Results: The sequence similarity of the DENV envelope C3–C30 and C302–C333 regions against the Pep42 cyclic peptide suggest these regions are possible recognition sites for GRP78. C3–C30 has a more similar grand average hydrophobicity index to that of Pep42 and a more negative binding affinity toward GRP78. Conclusion: We predict this region (C3–C30) of the DENV envelope to be the recognition site of GRP78. Further experimental validation will be important to future studies.

引用本文（GB/T 7714）

Abdo A. Elfiky, Ahmed Amr, A.I. Mosaad, 等. Cs-GRP78 Recognition Site on Dengue Virus Envelope Protein:<i>in silico</i>perspective[J]. Future Virology, 2023.

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DOI：https://doi.org/10.2217/fvl-2022-0192

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