[Effect of P-coumaric Acid on Apoptosis of Multiple Myeloma Cells Based on Oxidative Stress].

Zhu-Fa Hou、Bingjie Zhao、Songshan Liu、Wen-Jing Yi、Hong Che

2023PubMedMedicine被引 2

摘要

OBJECTIVE: To investigate the effect of p-coumaric acid on apoptosis of multiple myeloma cells and its related mechanism. METHODS: . The apoptosis, ROS fluorescence intensity and mitochondrial membrane potential of MM.1s cells were detected by flow cytometry, and the relative expressions of cellular Nrf-2 and HO-1 protein were detected by Western blot. RESULTS: <0.01). CONCLUSION: P-coumaric acid can inhibit the proliferation of MM.1s cells and may target the Nrf-2/HO-1 signaling pathway to affect oxidative stress in MM cells thereby inducing their apoptosis.

引用本文（GB/T 7714）

Zhu-Fa Hou, Bingjie Zhao, Songshan Liu, 等. [Effect of P-coumaric Acid on Apoptosis of Multiple Myeloma Cells Based on Oxidative Stress].[J]. PubMed, 2023.

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DOI：https://doi.org/10.19746/j.cnki.issn.1009-2137.2023.02.018

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