自噬在缺血性脑卒中过程中的作用及其调节机制研究进展
摘要
<p indent="0mm">Ischemic stroke is a severe cerebrovascular disease that is associated with high morbidity, disability, and mortality. Ischemia activates neuronal autophagy; however, the contribution of autophagy in ischemic brains remains controversial. Autophagy is an intracellular process by which cells degrade damaged organelles and macromolecules via lysosomal pathways. Emerging evidence suggests that autophagy ameliorates ischemic stroke through a variety of mechanisms. Here, we summarize the pathological events that may trigger autophagy in ischemic brains and discuss how autophagy may impact the process of ischemic stroke. We also review the regulatory mechanisms of autophagy in the process of cerebral ischemia and summarize the bioactive compounds that are known to regulate autophagy in ischemic brains. We aim to update the knowledge regarding autophagy in cerebral ischemia and provide new insights into novel drugs for stroke therapy.