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Safety evaluation of Eugenia jambolana seed extract

Jayanta、Sankhari、Ravirajsinh、NJadeja、Menaka、Thounaojam、Ranjitsinh、Devkar

2010Acta Scientiarum Naturalium Universitatis SunyatseniMedicine被引 2

摘要

) was assumed to be >5 000 mg/kg BW.In the sub-chronic toxicity evaluation, no adverse observations were recorded in mice administered with 2 000 mg/kg BW of EJSE; however at 3 000 mg/kg BW dose,moderately significant increase in the plasma levels of urea and creatinine was observed.Hence,the lowest observable adverse effect level（LOAEL） for EJSE was found to be 3 000 mg/kg BW and the no observable adverse effect level（NOAEL） was adjudged as 2 000 mg/kg BW.Conclusions:It can be concluded from this study that,orally administered EJSE is safe up to a10 fold higher dose than its reported therapeutic dose.

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