Icariin on relaxation effect of corpus cavernosum smooth muscle

Zhongcheng、Xin、Kim Kim、Euikyung、Zhenji、Tian、Guiting、Lin

2001中国科学通报：英文版Medicine被引 5

摘要

NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine 5’ monophosphate (GMP) by phos-phodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4×10-4 mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum believed to have the inhibiting effect on PDE5 and activation of NO-cGMP pathway to enhancing penile erection.

引用本文（GB/T 7714）

Zhongcheng, Xin, Kim Kim, 等. Icariin on relaxation effect of corpus cavernosum smooth muscle[J]. 中国科学通报：英文版, 2001.

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