The Uniform Carcinogenic Action of Alkylnitrosoureas in Syrian Hamsters
摘要
The carcinogenic effects of a number of alkylnitrosoureas in Syrian golden hamsters have been compared by administering them by gavage as solutions in corn oil/ethyl acetate.The compounds were methyl-,ethyl-,2-hydroxyethyl-,2-oxopropyl-,and 2-phenylethylnitrosourea and the dialkylnitrosoureas dimethyl- and diethylnitrosourea,ethylnitrosohydroxyethylurea, ethylnitroso-2-oxopropylurea,2-oxopropylnitrosochloroethylurea,and hydroxyethylnitroso- ethylurea.All were given at approximately equimolar doses and,in most cases,to male and female hamsters.Most of the hamsters died with tumors associated with the treatments.Methyl- nitrosourea,ethylnitrosourea,and hydroxyethylnitrosourea,but not oxopropylnitrosourea, gave rise to a high incidence of tumors of the forestomach,while the dialkylnitrosoureas pro- duced smaller numbers of forestomach tumors.All of the alkylnitrosoureas induced hemangio- sarcomas of the spleen,which was the most common tumor produced by these carcinogens. Tumors of other types were uncommon,except that ethylnitrosourea and ethylnitrosohydroxy- ethylurea induced tumors of the cervix in about half of the animals and ethylnitrosooxopropyl- urea induced some nervous system tumors.The small number of common target organs of alkylnitrosoureas in hamsters contrasted sharply with the broad spectrum of tumors they in- duced in rats,depending on the nature of the alkyl groups,and with a quite different order of potency in the latter species,1989 Academic Press.Inc.