Selective cleavage of phenolic tert-butyldimethylsilyl ethers using simple organic nitrogen bases
摘要
Simple organic nitrogen bases, such as Et3N, pyridine, DBU, etc., were found to be convenient and useful reagents for deprotection of TBDMS groups on acidic hydroxyl groups. The efficiency of these bases has an apparent order: 1 degrees amine >2 degrees amine > 3 degrees amine and aliphatic base > aromatic base. In aqueous DMSO and at room temperature, phenolic TBDMS ethers were removed selectively in the presence of alcoholic TBDMS ethers. And catalytic base can make these reactions complete. This method is high-yielding, fast, clean, safe and cost-effective. (C) 2009 Ji Jun Xue. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用本文（GB/T 7714）
Zhu, Jian JIAN, Rong Rong, 等. Selective cleavage of phenolic tert-butyldimethylsilyl ethers using simple organic nitrogen bases[J]. Lanzhou University Institutional Repository, 2010.
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