Prognositic factors and clinicopathologic characteristics of small gastrointestinal stromal tumor of the stomach： a retrospective analysis of 31 cases in one center
摘要
Objective:To analyze the clinicopathologic characteristics and prognostic factors of small gastrointestinal stromal tumor(GIST) of the stomach.Methods:A total of 31 small gastric GIST patients,including 10 males and 21 females,with a median age of 58 years(37-81 years),who underwent surgery at any time from 1999 to 2012 were included in this study.The clinical records of the patients were analyzed retrospectively.Results:Abdominal discomfort and pain(10 cases,32.3%,respectively) were the two most common complaints among the patients.All patients received surgery,11 received gastric wedge resection,11 received subtotal gastrectomy,5 received laparoscopic gastric wedge resection,and 4 received endoscopic submucosal dissection.No severe adverse complication was observed.A total of 29 patients(93.5%) were followed up.During the follow-up,2 patients were found to exhibit tumor recurrence,and 1 patient had liver metastases.One patient died of tumor progression,while another died of another malignant tumor.Median progression free survival(PFS) time was 120.3 months,and median overall survival(OS) time was 130.4 months.Conclusion:Small gastric GIST has better prognosis.Surgery is the best choice for therapy.Micro-invasive procedures are safe and effective for elective patients.Tumor necrosis,tumor bleeding,and muscle invasion are potential prognostic factors of small gastric GIST.