A Study of Immunological Indices for Diagnosis of Chronic Berylliosis
摘要
The results of the Be-induced leukocyte migration inhibition test(Be-MIT),the lymphocytetransformation test(LI),the E-rosette formation test(E-RFC),the old tuberculin test(OT),andsero-immunoglobulin(IgG,IgA,IgM)measurements on 13 cases of berylliosis,44 members ofthe observation group,and 51 members of the contact group are reported.In the Be-MIT,2 ofthe berylliosis patients were new cases that had been diagnosed and treated for a long time,andboth tested positive(18%).Fourteen patients from the observation group tested positive(32%),and 15 from the contact group tested positive(30%).The 8 cases in the control group testednegative;7 patients from the observation group and 3 of the berylliosis cases tested negative afterbeing treated.The lymphocyte transformation rates of the observation group and the berylliosisgroup were significantly lower than that of the control group(P<0.01).Both Et-RFC and Ea-RFC contents in the group with berylliosis were much lower than those in the control group(P<0.01).OT tests were performed on 8 berylliosis patients and 10 healthy men.Seven patientsshowed negative reactions and one showed a positive reaction.All the healthy men showedpositive reactions.The IgG and IgA levels of the observation group were significantly higherthan those of the control group(P<0.01).The Be-MIT could detect active beryllium disease atan early stage as well as Be-sensitive individuals.This test could be used as a supplementarydiagnostic index for the differential diagnosis of berylliosis and for the evaluation of a curativeeffect.1989 Academic Press,Inc.