Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro

Xü、Wensheng、Zhao、Ke-Kai、Miao Miao、Xiaohui、Ni、Wu

2010Acta Scientiarum Naturalium Universitatis SunyatseniMedicine被引 8

摘要

AIM:To determine the antiviral mechanism or target of oxymatrine against hepatitis B virus(HBV).METHODS:HepG2.2.15 cells were incubated with culture medium containing 500 μg/mL of oxymatrine for 2 and 5 d.The surface antigen of HBV(HBsAg) and e antigen of HBV(HBeAg) in supernatant were determined by ELISA.HBV DNA in supernatant,and intracellular covalently closed circular DNA(cccDNA),relaxed circular DNA(rcDNA) and pregenomic RNA(pgRNA) were quantif ied by specif ic real-time polymerase chain reaction(PCR) ...

引用本文（GB/T 7714）

Xü, Wensheng, Zhao, 等. Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2010.

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