Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide

Mohamed、Zaouali、İsmail、Ben、Mosbah、Eleonora、Boncompagni、Hassen Hassen

2010Acta Scientiarum Naturalium Universitatis SunyatseniMedicine被引 16

摘要

AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand ...

引用本文（GB/T 7714）

Mohamed, Zaouali, İsmail, 等. Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2010.

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