Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro
摘要
phase.Morphologic changes such asintact cell membrane,nucleic condensation,apoptotic body formation were seen undertransmission electronmicrescopy,whereas the0.5 mol/L arsenic trioxide-treated BEL-7402cells showed decrease of nucleocytoplasmicratio,round nucleus,well-differentiatedorganelles in the cytoplasm.The processes andmicrovilli on the cell surface of the experimentalgroups under scanning electron microscopy weresignificantly decreased.High expressions ofBcl-2 and Bax were detected in 1 and 2 μmol/Larsenic trioxide-treated cells,these were 46%,87.33% and 83.08%,95.83% respectively,among which that of Bax was more significant.Arsenic trioxide treatment at 0.5 μmol/Lresulted in a higher
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Xu, Hy, Yang, 等. Effect of arsenic trioxide on human hepatoma cell line BEL-7402 cultured in vitro[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2000.
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