Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model
摘要
Objective:To observe the combination effect of doxorubicin and Citrus hystrix(kaffir lime’s)peel ethanolic extract(ChEE)on blood serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)activity and cardio-hepato-histopathology of female Sprague Dawley rats.Methods:Doxorubicin and ChEE(5 rats per group)were administered in five groups of 3 rats each for 11 d.Group I:doxorubicin(dox)4.67 mg/kg body weight;Group II:dox+ChEE 500 mg/kg body weight;Group HI:dox+ChEE 1000 mg/kg body weight;Group IV:ChEE 1000 mg/kg body weight;Group V:untreated(control).Results:ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats,but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.Conclusion:ChEE has potency to be developed as cardioprotector agent in chemotherapy.