Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro

Yunlang、Cai、Xiaoqiang、�. Tan、Jun、Liu、Yang、Shen

2014Acta Scientiarum Naturalium Universitatis SunyatseniBiochemistry, Genetics and Molecular Biology被引 36

摘要

The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis.

引用本文（GB/T 7714）

Yunlang, Cai, Xiaoqiang, 等. Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2014.

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