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The action of Pseudomonas aeruginosa biofilms in intrinsic drug resistance

Xie、Yi ̆、Jia Jia、Wenxiang wenxiang、Zeng、Wei Wei、Yang Yang、Weiqing

2005中华医学杂志：英文版Biochemistry, Genetics and Molecular Biology被引 1

摘要

0.05). The carbonyl cyanide m-chlorophenylhydrazone and azithromycin could significantly reduce the drug resistance of biofilm strains and efflux pump strains.Conclusions In the development of P. aeruginosa biofilms, the strains of gyrA mutation and MDR efflux could be conferred with new level of drug resistance. When co-cultured mutated strains with biofilm strains, biofilms may play a major role in bacterial resistance. But after 72 hours incubation (a mature biofilms had been developed), there was no clearly difference between the number of mutant strains an

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