NaYF<sub>4</sub>:Yb/Er-碳纳米管功能纳米材料的制备、表征及其在肿瘤细胞的靶向检测和治疗中的应用
摘要
NaYF4:Yb,Er-MWCNT-FA composite nanomaterials were obtained by conjugating the carbon nanotubes with folic acid and 2,3-dimercaptosuccinic acid functionalized NaYF4:Yb,Er nanoparticles via an amide bond. Their morphology, structures, fluorescent and target imaging properties were characterized by means of TEM, XRD, UV-Vis, PL and confocal laser scanning microscopy (CLMS). The results of CLMS demonstrated that the functional composites had a high effectiveness to detect cancerous cell lines overexpressing the folate receptor (Hela cell) from normal cells (HLF cell) by tracing the fluorescence imaging with high fidelity. Furthermore, DOX was successfully loaded to the prepared NaYF<sub>4</sub>:Yb,Er-MWCNT-FA nanomaterials mainly through noncovalent π-π interactions, which had obvious antitumor activities and achieved targeted diagnosis and therapy of tumor cell simultaneously.