Gastroprotective effect of Achyranthes aspera Linn,leaf on rats
摘要
Objective:The study was aimed al evaluating the antiulcer activity of ethanolic extract of Achyranthes aspera(EEAA) leaf.Methods:The anti-ulcer assays were performed on pylorus ligation and chronic ethanol induced ulcer model.The effects of the EEAA on gastric content volume,pH.free acidity,total acidity and ulcer index were evaluated.Results:The percentage of ulcer protection(59.55%and 35.58%) was significantly(P < 0.001) higher in the groups treated with the high dose of EEAA(600 mg/kg),it also reduced the volume of gastric juice and total acidity whereas,gastric pH was increased signiGcandy.Conclusions:The results of this study show significant gastroprotective activity of EEAA may be due to presence of phyto-constituents like flavanoids,saponins and tannins.