CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis
摘要
AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in mice.METHODS:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the anus.Colonic morphology was examined by hematoxylin and eosin staining.Colonic cytokines were determined by enzyme-linked immunosorbent ...
引用本文（GB/T 7714）
Xia, Xianming, Wang, 等. CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2010.
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