An analytical method for Fe（II） and Fe（III） determination in pharmaceutical grade iron sucrose complex and sodium ferric gluconate complex
摘要
A robust voltammetric method has been developed and validated for the determination of Fe(Ⅱ) and Fe(Ⅲ) in pharmaceutical iron polysaccharidic complexes. Undesirable low molecular weight iron complexes, at concentration about 3% in the pharmaceutical formulation, can be easily determined with good accuracy and precision. This methodology can be proposed as a viable, environmentally sustainable substitute for the conventional Normal Pulse Polarographic method in US Pharmacopeia, with better analytical figures of merit, and reduced Hg consumption. A deeper insight in Fe(Ⅱ) and Fe(Ⅲ) composition can be gained by the combined use of a new potentiometric technique after chemical decomposition of the complex.
引用本文（GB/T 7714）
Danièle, Merli, Antonella, 等. An analytical method for Fe（II） and Fe（III） determination in pharmaceutical grade iron sucrose complex and sodium ferric gluconate complex[J]. 药物分析学报：英文版, 2012.
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