Integration of animal behaviors under stresses with different time courses
摘要
We used animal models offorced swim stressandchronic unpredictable tried to reveal whether a passive coping style of high flotation behavior in forced swim stress predicts anhedonia behavior after chronic unpredictable stress,and whether the dopamine system regulates floating and anhedonia behaviors.Our results confirmed that depression-prone rats usefloating behavioras a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress.Intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals,but increased sucrose preference in rats showing anhedonia.These data indicate that floating behavior is a defensive mode that is preferred by susceptible individuals under conditions of acute stress.Simultaneously,these animals more readily experienced anhedonia under long-term stress;that is,they were more readily affected by depression.Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia.