A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Alain Chebly、Fadi Haddad、Josiane Bassil、Tony Yammine、Rima Korban、Warde Semaan、Fady El Karak、Hampig Raphaël Kourié

2020Leukemia Research ReportsMedicine被引 2开放获取

摘要

Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.

引用本文（GB/T 7714）

Alain Chebly, Fadi Haddad, Josiane Bassil, 等. A rare case of acute myeloid leukemia with t(12;19)(q13;q13)[J]. Leukemia Research Reports, 2020.

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DOI：https://doi.org/10.1016/j.lrr.2020.100216

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