[Application value of immature granulocyte count in predicting early infection after spinal operation].
摘要
OBJECTIVE: To evaluate the early predictive value of immature granulocytes(IGs) in postoperative infection in patients with spinal injury. METHODS: The clinical data of 78 patients with spinal cord injury underwent surgery from October 2016 to October 2018 were collected. There were 57 males and 21 females, aged from 45 to 63 years old with an average of (55.2±6.1) years. The most common cause of injury was spinal trauma or degeneration. According to the American Spinal Cord Injury Association (ASIA) classification of spinal cord injury, 37 cases were complete injury(grade A and B) and 41 cases were incomplete injury (grade C and D). All the 78 patients showed different degrees of deep and shallow sensory disturbances, and underwent CT and MRI examinations after admission. According to whether the secondary infection occurred within 1 week after surgery, the patients were divided into infected group and non-infected group. At the time of admission and 1, 3, 6 days after surgery, the immature granulocyte absolute value(IG#), immature granulocyte percentage(IG%), C-reactive protein(CRP), procalcitonin(PCT), interleukin-1β(IL-1β), interleukin-6(IL-6), and tumor necrosis factor-α (TNF-α) were detected. Using ROC curve to compare the predictive value of IG%, IG#, and PCT in early detection of postoperative infection. The correlation between IG%, IG# and PCT was analyzed using the Spearman correlation test. RESULTS: <0.001). CONCLUSIONS: The elevated levels of IG%, IG# and PCT in patients with spinal cord injury within 24 hours after surgery have high sensitivity and specificity for predicting early secondary infection. Postoperative quantification of these indicators helps early identification of patients with high risk of infection.