Paradoxical role of Kupffer cells on ischemia/reperfusion injury in liver transplantation

2009国际外科学杂志Medicine被引 1

摘要

Kupffer cells, the resident macrophages of the liver, play an important role in ischemia/reperfusion(L/R)injury in liver transplantation. 1schemic liver is reperfused through portal vein, and then Kupffer cells are activated. The liver is damaged by the released reactive oxygen species, inflammatory mediators and cytokines. On the other hand, upregulation of HO-1, induced by the activated kupffer cells, exerts a cytoprotective function for the IYR injury in liver transplantation models. Thus, Kupffer cells play the dual role on L/R injury in liver transplantation. Key words: Kupffer cells; ischemia/reperfusion injury; liver transplantation

引用本文（GB/T 7714）

Hanfei Huang, Zhong Zeng. Paradoxical role of Kupffer cells on ischemia/reperfusion injury in liver transplantation[J]. 国际外科学杂志, 2009.

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DOI：https://doi.org/10.3760/cma.j.issn.1673-4203.2009.02.009

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