Clinical analysis of 2 300 kidney transplantations
摘要
Objective To analyze the clinical data of 2 300 renal transplantations from 1972 to Oct. 2000. Methods The graft survival rate at 1, 3, 5 year, main complications of renal transplantation and treatment, the factors contributive to the mortality and the factors affecting the re-transplant grafts’ survival rate were observed. HLA-antigen-gene typing and population response antibody (PRA) was detected.Results The graft survival rates at 1, 3, 5 years were 87.33%, 80.17% and 67.04% respectively after administration of CsA since 1985. In the 353 recipients aged over 50 years, one year graft survival rate was 83.44% and 1 year patient survival rate 85.43%. Cardiocerebral vascular diseases were the main diseases, accounting for 50.7% of the factors of death after renal transplantation, infection for 13.5%. The incidence of the malignancy was 1.46% (25/1 580). The incidence of acute rejection was 27%, 35.5%, 22.4%, 20.85%, 0, 0 respectively when the HLA mismatches were 6, 5, 4, 3, 2 and 1. Conclusion Good HLA match, rational use of immunosuppressants after renal transplantation, the prevention of post-transplantation complications and immediate treatment were the main factors improving long-term graft/patient survival rate.