Hypoglycemia caused by colchicine
摘要
A 71-year-old male patient received sodium bicarbonate 1.0 g and colchicine 0.5 mg orally thrice daily, and benzbromarone 50 mg orally once daily for hyperuricemia with left ankle joint pain. On the first day, the patient took sodium bicarbonate and colchicine about 1 hour after dinner and developed palpable sense of hungry, accompanied with palpitations, vertigo, fatigue, and watery stool about 1 hour after the medication. The above symptoms relieved after having a small amount of porridge. On the second day, the above symptoms appeared after each dose and could relieve after eating a little food. On the third morning, the patient was found coma by a family member and admitted to hospital emergency department. On account of the random fingertip capillary and fasting venous blood glucose of 1.0 mmol/L and 1.8 mmol/L, the patient was immediately given 40 ml of 50% glucose injection intravenously, followed by intravenous infusion of a mixture, which contained 20 ml of 50% glucose injection and 500 ml of 10% glucose injection. Five minutes after the intravenous injection, the patient began to regain consciousness. Nine minutes after the intravenous injection, the patient′s consciousness was fully recovered and he could answer questions correctly. On day 2 after the hospitalization, the patient′s blood glucose level returned to normal and he had no discomfort symptoms. The patient continued to take benzbromarone and sodium bicarbonate after discharge and did not have hypoglycemia at 1 year of follow-up. Key words: Colchicine; Hypoglycemia