Orthotopic liver transplantation to treat patients with fulminant Hepatitis-B
摘要
Objectives To investigate the therapeutic effects of orthotopic liver transplantation in the treatment of fulminant hepatitis-B and the efficiency of lamivudine on recurrence of hepatitis-B.Methods'Seven patients with fulminant hepatitis-B received orthotopic liver transplantation under venovenous bypass.All patients had serious jaundice,ascites and hemorrhagic tendency,and of whom 5 were associated with encephalopathy,1 with acute renal failure,and 1 with gastrohemorrhage.Results Five patients survived for 2 to 6 months after transplantation,2 died of multi-organ failure or recurrence of fulminant hepatitis-B.No recurrence of hepatitis-B was found in the 5 survival patients taking lamivudine.Conclusions Orthotopic liver transplantation is an effective therapy for fulminant hepatitis-B,and lamivudine may prevent recurrence of hepatitis-B after transplantation. Key words: Liver transplantation; Hepatitis B; Liver failure,acute