[Efficacy of repeated application of praziquantel in treatment of hepatic fibrosis due to schistosomiasis].
摘要
OBJECTIVE: To evaluate the efficacy of repeated application of praziquantel in the treatment of hepatic fibrosis due to schistosomiasis. METHODS: A total of 60 patients with schistosomiasis hepatic fibrosis (clinically diagnosed cases) were selected and divide into a treatment group and control group randomly, with 30 cases each group. The patients in the treatment group were given praziquantel［30 mg/ (kg·d) for 2 days］each year for three consecutive years, on the basis of the conventional liver protection therapy and symptomatic treatment. The patients in the control group were given the conventional liver protection therapy and symptomatic treatment. All the treatment duration was 36 months. The clinical symptoms were observed, and the liver function, and the levels of HA, LN, IV-C, and PCIII were detected in the two groups before and after the treatment. RESULTS: < 0.05). CONCLUSIONS: The repeated application of praziquantel has a better therapeutic efficacy in the treatment of hepatic fibrosis due to schistosomiasis.