[Interference of Lumican Regulates the Invasion and Migration of Liver Cancer Cells].

Qi-Ming Mu、Wei He、Guimin Hou、Yong Liang、Gang Wang、Chunlin Li、Bo Liao、Xin Liu

2018PubMedBiochemistry, Genetics and Molecular Biology被引 6

摘要

OBJECTIVE: To explore the effect of silencing lumican on the invasion and migration of liver cancer cells. METHODS: Lumican was silenced by shRNA in liver cancer cells (HepG2 and MHCC97H). The mRNA levels of lumican were detected by qRT-PCR. Cell invasion was measured by Transwell. Cell migration was tested via wound healing. The protein levels of lumican,MMP-9,VEGF,ERK1,JNK,p-ERK1 and p-JNK were measured by Western blot. RESULTS: <0.01). CONCLUSION: Silencing lumican by shRNA attenuates the invasion and migration of liver cancer cells via inhibiting the activation of ERK1/JNK pathway.

引用本文（GB/T 7714）

Qi-Ming Mu, Wei He, Guimin Hou, 等. [Interference of Lumican Regulates the Invasion and Migration of Liver Cancer Cells].[J]. PubMed, 2018.

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