[Study on Construction of Recombinant Bb-pGEX-<i>OprI</i> Vaccine of <i>Pseudomonas aeruginosa</i> and Its Protection Effect].
摘要
OBJECTIVE: (Pa) outer membrane protein I (OprI) and study its protection effect in mice against Pa. METHODS: ,Bb-pGEX-1λT and Bb respectively. All mice were challenged with PA01 strain at 4 weeks after the first vaccination. At 2 weeks after the challenge,mice were sacrificed to separate their lungs,and the numbers of bacterial colonies in lungs were counted. Venous blood was collected before vaccination,at 4 weeks after the first vaccination and 2 weeks after the challenge of PA01 strain. The serum IgG,IgG subclasses and IgE were detected by routine ELISA. RESULTS: <0.05). CONCLUSION: vaccine was successfully constructed and produced an effective humoral immune response against the Pa infection.
引用本文（GB/T 7714）
Xiao Liu, Wengui Li, Guang-Xu Luo. [Study on Construction of Recombinant Bb-pGEX-<i>OprI</i> Vaccine of <i>Pseudomonas aeruginosa</i> and Its Protection Effect].[J]. PubMed, 2018.
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