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丝状病毒感染的动物模型

Vinayakumar SiragamVinayakumar Siragam王颂基邱香果Gary WongXiangguo Qiu

2018动物学研究Medicine被引 49开放获取

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摘要

, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

引用本文(GB/T 7714)

Vinayakumar Siragam, Vinayakumar Siragam, 王颂基, 等. 丝状病毒感染的动物模型[J]. 动物学研究, 2018.

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DOI:https://doi.org/10.24272/j.issn.2095-8137.2017.053

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