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[Sodium Ferulate Attenuates Oxidative Stressvia Suppressing NALP3 Inflammasome and ERK Signal Pathway].

Xiaolin Wei、Min Xie、Gaoyan He

2016PubMedBiochemistry, Genetics and Molecular Biology被引 3

摘要

OBJECTIVES: Study the gene and protein expression of NACHT-PYD-containing protein 3 (NALP3) inflammasome and extracellular regulated protein kinase (ERK), the intervention effects of sodium ferulate (SF) in human lung epithelial cells A549 under oxidative stress, and to investigate the possible mechanism. METHODS: , the expression of caspase-1, NALP3, phosphorylated ERK p-ERK, ERK protein were evaluated by Western blot. The level of interleukin-1 β (IL-1β) were detected by ELISA. RESULTS: <0.05),when compared with the H₂O₂ group. CONCLUSIONS: SF may reduce the expression of caspase-1, NALP3 and IL-1β by inhibiting ERK, so as to reduce the inflammation caused by oxidative stress.

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