HBV研究常用的动物模型

郭伟娜、Weina Guo、朱彬、艾灵、杨东亮、王宝菊、Bin Zhu、Ling Ai

2018动物学研究Medicine被引 43开放获取

摘要

Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.

引用本文（GB/T 7714）

郭伟娜, Weina Guo, 朱彬, 等. HBV研究常用的动物模型[J]. 动物学研究, 2018.

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DOI：https://doi.org/10.24272/j.issn.2095-8137.2018.013

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