A transgenic monkey model for the study of human brain evolution

2019动物学研究Biochemistry, Genetics and Molecular Biology被引 13开放获取

摘要

Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (primary microcephaly1, <i>MCPH1</i>) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution.

引用本文（GB/T 7714）

Lei Shi, Bing Su. A transgenic monkey model for the study of human brain evolution[J]. 动物学研究, 2019.

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DOI：https://doi.org/10.24272/j.issn.2095-8137.2019.031

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