尾状核-眶部内侧前额叶的功能连接与反应性攻击的关系：基于静息态功能磁共振研究
摘要
<p id="C2">Reactive aggression has been widely concerned by researchers because of its serious impact on society, such as violent crimes. Existing neuroimaging studies using patients with high levels of aggression indicated a network of brain regions subserve reactive aggression, including amygdala, caudate nucleus, and orbitofrontal cortex. Furthermore, researchers believed that reduced prefrontal activity along with heightened subcortical activity in the context of provocative stimuli poses an increased risk for reactive aggression. However, evidence for this theory in healthy population is lacking, especially this independently of the experiment task. <p id="C100">In this study, the modified TAP was used and the punishment levels selected for the virtual opponents serve as indicator of reactive aggression. Based on the previous researches, Orbitomedial Prefrontal (OMPFC) was selected as the seed to investigate the relationship of reactive aggression and the connectivity between OMPFC and other brain regions using resting state fMRI. Thirty-night undergraduates (mean age = 20.05 ± 0.92 years old) were enrolled in the experiment. The resting state functional magnetic resonance (rs-fMRI) data was acquired using Echo Planar Imaging (EPI) sequence from a 3-T Siemens Magnetom Trio scanner (Siemens Medical, Erlangen, Germany). This scanning acquired 242 volumes with TR = 2 s (lasting 8 min and 8 sec). rs-fMRI data was processed and analyzed using the REST (Resting-State fMRI Data Analysis Toolkit) toolbox to calculate Functional Connectivity (FC) and Granger Causality Analysis (GCA), which reflects the functional and effective connectivity among different areas, respectively. The results of FC indicated that the functional connectivity between the left OMPFC and right angular gyrus, left OMPFC and bilateral caudate nucleus, right OMPFC and right caudate nucleus were significantly correlated with the reactive aggression. Furthermore, the follow-up GCA indicated that the