Interchromosomal {\sl trans}--splicing of {\sl DMRT1} gene on chicken chromosome Z
摘要
Sex determination/differentiation is the only developmental process involving tw o types of cell divisions (mitosis and meiosis). Analysis of transcription of ke y gene DMRT1 in the process showed that DMRT 1 gene on the chromosome Z was trans-spliced with CENP C 1 on the chromosome 4, CD5R on the chromosome 5 and 37LRP/p40 on the chromosome 2, which composed a rare form of transcripts DMRT1-CENP C1, DMRT1 -CD5R and DMRT1-37LRP/p40 respectively. Over lapping regions between splicing sites on both chromosomes were observed, which would play an important role in the interchromosomal trans-splicing. The findin gs that multiple genes on different chromosomes are trans-spliced simultaneousl y with the DMRT1 during transcription undoubtedly help in understanding diversity of gene regulations at transcriptional level and sex determination and differentiation mechanisms.