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[Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles].

LU Xiao-dong、Geng-sheng Zhao

1990PubMedBiochemistry, Genetics and Molecular Biology被引 1

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摘要

The effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel.

引用本文（GB/T 7714）

LU Xiao-dong, Geng-sheng Zhao. [Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles].[J]. PubMed, 1990.

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