[Epidemic status of drug-resistant Mycobacterium tuberculosis in Shandong province, China].
摘要
OBJECTIVE: To analyze the present epidemic status of drug-resistant Mycobacterium tuberculosis (MTB) in Shandong Province of China, as compared with findings of survey for drug-resistant MTB in 1997, and therefore to provide valuable data for making the current control policy of drug-resistant MTB. METHODS: From October 2004 to December 2011, the culture positive sputum samples of all 5916 new registered sputum smear-positive TB patients at the county-level TB dispensaries were tested for drug susceptibility. Finally 5542 cases with test results were included in the analysis. Of the total cases, 4198 were male and 1344 were female. The age range of the patients were 15 to 92 years old and the average age was (51 ± 20) years old, among whom, 1304 were ≤ 29 years old, 2106 were from 30 to 59 years old and 2132 were ≥ 60 years old. Of all the cases, 4332 (78.2%) only received initial treatment and 1210 (21.8%) received retreatment. The SPSS 13.0 was used for statistical analysis and χ(2) test was used to compare category, gender, and age groups of patients. RESULTS: The total drug resistance (TDR) rate was 19.4% (1075/5542), which was lower than 23.4% (288/1229) in 1997 in Shandong Province (χ(2) = 10.193, P < 0.01). The rates of single drug resistance (SDR), multidrug resistance (MDR) and poly-drug resistance (PDR) were 11.3% (629/5542), 3.7% (203/5542) and 4.4% (243/5542), respectively. The TDR rate in patients with initial treatment was 19.0% (822/4332), and 62.7% (515/822) of which was SDR. The TDR rate of patients with retreatment was 20.9% (253/1210), and 54.9% (139/253) of which tended to be MDR or PDR. Among TDR patients, those with initial treatment accounted for 76.5% (822/1075) and SDR patients accounted for 58.5% (629/1075). The MDR rate of patients with initial treatment was 2.9% (124/4332) and the rate of patients with retreatment was 6.5% (79/1210), the differences being significant (χ(2) = 36.032, P < 0.01). The TDR rate, initial TDR rate, and retreatme