[The study of autoantibodies in women with habitual abortion of unknown etiology].
摘要
OBJECTIVE: To evaluate the relationship between habitual abortion of unknown etiology and autoantibodies. METHODS: IgG and IgA antibodies against cardiolipin, specific antinuclear double-stranded DNA and single-stranded DNA were measured by enzyme linked immunosorbent assay (ELISA). Antinuclear antibody, smooth muscle antibody, antimitochondrial antibody and antiheart muscle antibody were performed by indirect immunofluorescence assay. Antiextractable nuclear antigen's antibodies were determined by immunodiffusion assay. RESULTS: Most women with habitual abortion of unknown etiology showed higher incidence of antibodies to cardiolipin, nuclear, smooth muscle compared with normal multigravida control (P < 0.05). CONCLUSIONS: These results indicate that most women with habitual abortion of unknown etiology have a higher level of autoreactivity, which may affect the course of pregnancy. The incidence of antismooth muscle antibody in women with habitual abortion of unknown etiology is also increased compared with normal multigravida control.